Drug interactions
Istradefylline + Tinidazole
Severity: Minor
Istradefylline and Tinidazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Istradefylline at the 40 mg/day dose weakly inhibits CYP3A4 and can raise exposure to CYP3A4 substrates. Tinidazole is partly metabolized by CYP3A4, so its levels may rise modestly, increasing the chance of dose-related adverse effects such as nausea or metallic taste.
What this interaction means in plain words
Istradefylline and Tinidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Istradefylline belongs to Central Nervous System; Tinidazole belongs to Anti Parasitic.
Why it happens
Istradefylline at higher doses inhibits intestinal and hepatic CYP3A4, reducing tinidazole clearance.
What to do
No routine dose change is needed for standard short tinidazole courses. Watch for gastrointestinal or neurological adverse effects if istradefylline 40 mg/day is used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Istradefylline and Tinidazole, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Tinidazole
- Disulfiram + Tinidazole Contraindicated
- Ethanol + Tinidazole Major
- Fexinidazole + Tinidazole Major
- Lopinavir + Tinidazole Major
- Nilotinib + Tinidazole Major
- Ritonavir + Tinidazole Major
Other interactions of Istradefylline
Frequently asked questions
Can I take Istradefylline with Tinidazole?
MediHelp rates the interaction as minor. Istradefylline and Tinidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Istradefylline at the 40 mg/day dose weakly inhibits CYP3A4 and can raise exposure to CYP3A4 substrates. Tinidazole is partly metabolized by CYP3A4, so its levels may rise modestly, increasing the chance of dose-related adverse effects such as nausea or metallic taste.
How serious is the interaction between Istradefylline and Tinidazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed for standard short tinidazole courses. Watch for gastrointestinal or neurological adverse effects if istradefylline 40 mg/day is used.
What other medicines interact with Tinidazole?
MediHelp also lists interactions of Tinidazole with, for example, Disulfiram, Ethanol, Fexinidazole. The full list is on the Tinidazole page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
