Drug interactions
Itraconazole + Lofepramine
Severity: Major
Itraconazole and Lofepramine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lofepramine, a tricyclic antidepressant, can prolong the QT interval and cause arrhythmia. Itraconazole adds QT risk and may raise tricyclic levels through CYP3A4 inhibition.
What this interaction means in plain words
Itraconazole and Lofepramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive QT prolongation, with possible CYP3A4 inhibition raising lofepramine exposure.
What to do
Avoid if possible. If used together, monitor ECG and electrolytes and watch for anticholinergic and cardiac effects.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Frequently asked questions
Can I take Itraconazole with Lofepramine?
MediHelp rates the interaction as major. Itraconazole and Lofepramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lofepramine, a tricyclic antidepressant, can prolong the QT interval and cause arrhythmia. Itraconazole adds QT risk and may raise tricyclic levels through CYP3A4 inhibition.
How serious is the interaction between Itraconazole and Lofepramine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible. If used together, monitor ECG and electrolytes and watch for anticholinergic and cardiac effects.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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