Drug interactions
Itraconazole + Marijuana
Severity: Minor
Itraconazole and Marijuana: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
THC and CBD are partly metabolized by CYP3A4, so itraconazole may raise their concentrations. This could intensify sedation, dizziness, tachycardia and impaired psychomotor performance.
What this interaction means in plain words
Itraconazole and Marijuana have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
CYP3A4 inhibition reduces the metabolism of cannabinoids.
What to do
Advise patients to watch for increased sedation or palpitations, and lower the cannabinoid dose if effects are excessive.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Frequently asked questions
Can I take Itraconazole with Marijuana?
MediHelp rates the interaction as minor. Itraconazole and Marijuana have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. THC and CBD are partly metabolized by CYP3A4, so itraconazole may raise their concentrations. This could intensify sedation, dizziness, tachycardia and impaired psychomotor performance.
How serious is the interaction between Itraconazole and Marijuana?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to watch for increased sedation or palpitations, and lower the cannabinoid dose if effects are excessive.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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