Drug interactions
Itraconazole + Methylergonovine
Severity: Contraindicated
Itraconazole and Methylergonovine: contraindicated interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole raises methylergonovine concentrations. This can produce ergotism with severe vasospasm and cerebral or limb ischemia.
What this interaction means in plain words
Itraconazole and Methylergonovine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Strong CYP3A4 inhibition by itraconazole reduces methylergonovine metabolism.
What to do
Avoid the combination. Use an alternative uterotonic such as oxytocin or carboprost when needed.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Frequently asked questions
Can I take Itraconazole with Methylergonovine?
MediHelp rates the interaction as contraindicated. Itraconazole and Methylergonovine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Itraconazole raises methylergonovine concentrations. This can produce ergotism with severe vasospasm and cerebral or limb ischemia.
How serious is the interaction between Itraconazole and Methylergonovine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. Use an alternative uterotonic such as oxytocin or carboprost when needed.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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