Drug interactions
Itraconazole + Mobocertinib
Severity: Contraindicated
Itraconazole and Mobocertinib: contraindicated interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole raises mobocertinib exposure and both can prolong the QT interval, which may lead to torsades de pointes. Labeling advises avoiding strong CYP3A inhibitors with mobocertinib.
What this interaction means in plain words
Itraconazole and Mobocertinib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Strong CYP3A4 inhibition raises mobocertinib levels, with additive QT prolongation.
What to do
Avoid the combination and use a non-CYP3A-inhibiting antifungal. If unavoidable, reduce the mobocertinib dose per labeling and monitor ECG and electrolytes closely.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Frequently asked questions
Can I take Itraconazole with Mobocertinib?
MediHelp rates the interaction as contraindicated. Itraconazole and Mobocertinib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Itraconazole raises mobocertinib exposure and both can prolong the QT interval, which may lead to torsades de pointes. Labeling advises avoiding strong CYP3A inhibitors with mobocertinib.
How serious is the interaction between Itraconazole and Mobocertinib?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-CYP3A-inhibiting antifungal. If unavoidable, reduce the mobocertinib dose per labeling and monitor ECG and electrolytes closely.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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