Drug interactions
Itraconazole + Mometasone inhaled
Severity: Moderate
Itraconazole and Mometasone inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole inhibits CYP3A4 and can greatly raise systemic mometasone exposure. This may cause systemic corticosteroid effects including adrenal suppression and Cushingoid features.
What this interaction means in plain words
Itraconazole and Mometasone inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 inhibition reduces the clearance of absorbed mometasone.
What to do
Monitor for signs of hypercortisolism and adrenal suppression, especially with long-term use. Consider an alternative corticosteroid such as beclometasone if prolonged therapy is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Frequently asked questions
Can I take Itraconazole with Mometasone inhaled?
MediHelp rates the interaction as moderate. Itraconazole and Mometasone inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Itraconazole inhibits CYP3A4 and can greatly raise systemic mometasone exposure. This may cause systemic corticosteroid effects including adrenal suppression and Cushingoid features.
How serious is the interaction between Itraconazole and Mometasone inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of hypercortisolism and adrenal suppression, especially with long-term use. Consider an alternative corticosteroid such as beclometasone if prolonged therapy is needed.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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