Drug interactions
Itraconazole + Mometasone intranasal
Severity: Minor
Itraconazole and Mometasone intranasal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intranasal mometasone has very low systemic bioavailability, but itraconazole can raise its systemic levels through CYP3A4 inhibition. Clinically significant corticosteroid effects are possible mainly with prolonged use or high doses.
What this interaction means in plain words
Itraconazole and Mometasone intranasal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
CYP3A4 inhibition reduces the clearance of absorbed mometasone.
What to do
Usually no change is needed for short courses. With long-term co-use, watch for features of systemic corticosteroid excess.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Frequently asked questions
Can I take Itraconazole with Mometasone intranasal?
MediHelp rates the interaction as minor. Itraconazole and Mometasone intranasal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Intranasal mometasone has very low systemic bioavailability, but itraconazole can raise its systemic levels through CYP3A4 inhibition. Clinically significant corticosteroid effects are possible mainly with prolonged use or high doses.
How serious is the interaction between Itraconazole and Mometasone intranasal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Usually no change is needed for short courses. With long-term co-use, watch for features of systemic corticosteroid excess.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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