Drug interactions
Itraconazole + Octreotide
Severity: Moderate
Itraconazole and Octreotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have been associated with QT prolongation or bradycardia-related rhythm disturbances. Using them together may add modestly to arrhythmia risk, particularly in patients with other risk factors.
What this interaction means in plain words
Itraconazole and Octreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Itraconazole belongs to Anti Fungals; Octreotide belongs to Endocrine.
Why it happens
Additive pharmacodynamic effects on cardiac repolarization; octreotide mainly acts through bradycardia and conduction effects.
What to do
Obtain a baseline ECG and monitor QTc when combining, and correct potassium and magnesium disturbances. Review other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Octreotide
Frequently asked questions
Can I take Itraconazole with Octreotide?
MediHelp rates the interaction as moderate. Itraconazole and Octreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have been associated with QT prolongation or bradycardia-related rhythm disturbances. Using them together may add modestly to arrhythmia risk, particularly in patients with other risk factors.
How serious is the interaction between Itraconazole and Octreotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QTc when combining, and correct potassium and magnesium disturbances. Review other QT-prolonging drugs.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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