Drug interactions
Itraconazole + Olanzapine
Severity: Moderate
Itraconazole and Olanzapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can prolong the QTc interval, although olanzapine does so only rarely. Itraconazole may also modestly raise olanzapine exposure, so additive cardiac and sedative effects are possible.
What this interaction means in plain words
Itraconazole and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Itraconazole belongs to Anti Fungals; Olanzapine belongs to Central Nervous System.
Why it happens
Additive effects on cardiac repolarization; itraconazole may slightly reduce olanzapine clearance, though olanzapine is mainly cleared by CYP1A2 and glucuronidation.
What to do
Monitor ECG in patients with additional QT risk factors and watch for excessive sedation. Maintain normal electrolytes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Olanzapine
Frequently asked questions
Can I take Itraconazole with Olanzapine?
MediHelp rates the interaction as moderate. Itraconazole and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can prolong the QTc interval, although olanzapine does so only rarely. Itraconazole may also modestly raise olanzapine exposure, so additive cardiac and sedative effects are possible.
How serious is the interaction between Itraconazole and Olanzapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG in patients with additional QT risk factors and watch for excessive sedation. Maintain normal electrolytes.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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