Drug interactions
Itraconazole + Parecoxib
Severity: Minor
Itraconazole and Parecoxib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Parecoxib is converted to valdecoxib, which is cleared by CYP3A4 and CYP2C9. Itraconazole may raise valdecoxib levels, increasing the risk of NSAID adverse effects such as gastrointestinal, renal and cardiovascular events.
What this interaction means in plain words
Itraconazole and Parecoxib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
CYP3A4 inhibition reduces valdecoxib metabolism.
What to do
Use the lowest effective parecoxib dose for the shortest time. Monitor for gastrointestinal symptoms, blood pressure and renal function.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Itraconazole and Parecoxib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Frequently asked questions
Can I take Itraconazole with Parecoxib?
MediHelp rates the interaction as minor. Itraconazole and Parecoxib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Parecoxib is converted to valdecoxib, which is cleared by CYP3A4 and CYP2C9. Itraconazole may raise valdecoxib levels, increasing the risk of NSAID adverse effects such as gastrointestinal, renal and cardiovascular events.
How serious is the interaction between Itraconazole and Parecoxib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective parecoxib dose for the shortest time. Monitor for gastrointestinal symptoms, blood pressure and renal function.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
