Drug interactions
Itraconazole + Progesterone intravaginal
Severity: Minor
Itraconazole and Progesterone intravaginal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole may increase systemic progesterone exposure since progesterone is metabolized by CYP3A4. Vaginal administration limits first-pass metabolism, so the clinical effect is probably modest.
What this interaction means in plain words
Itraconazole and Progesterone intravaginal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
CYP3A4 inhibition by itraconazole reduces progesterone metabolism.
What to do
No routine dose change is needed. Watch for progestogenic adverse effects such as sedation, breast tenderness or bleeding changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Frequently asked questions
Can I take Itraconazole with Progesterone intravaginal?
MediHelp rates the interaction as minor. Itraconazole and Progesterone intravaginal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Itraconazole may increase systemic progesterone exposure since progesterone is metabolized by CYP3A4. Vaginal administration limits first-pass metabolism, so the clinical effect is probably modest.
How serious is the interaction between Itraconazole and Progesterone intravaginal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Watch for progestogenic adverse effects such as sedation, breast tenderness or bleeding changes.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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