Drug interactions
Itraconazole + Progesterone micronized
Severity: Moderate
Itraconazole and Progesterone micronized: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole may increase progesterone concentrations because oral micronized progesterone undergoes extensive CYP3A4 metabolism. This can enhance adverse effects such as drowsiness and dizziness.
What this interaction means in plain words
Itraconazole and Progesterone micronized can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 inhibition by itraconazole reduces progesterone metabolism.
What to do
Monitor for excessive sedation, dizziness and other progestogenic effects. Reduce the progesterone dose if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Frequently asked questions
Can I take Itraconazole with Progesterone micronized?
MediHelp rates the interaction as moderate. Itraconazole and Progesterone micronized can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Itraconazole may increase progesterone concentrations because oral micronized progesterone undergoes extensive CYP3A4 metabolism. This can enhance adverse effects such as drowsiness and dizziness.
How serious is the interaction between Itraconazole and Progesterone micronized?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation, dizziness and other progestogenic effects. Reduce the progesterone dose if symptoms occur.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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