Drug interactions
Itraconazole + Progesterone natural
Severity: Moderate
Itraconazole and Progesterone natural: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole may increase exposure to natural progesterone because it is cleared mainly by CYP3A4. The effect is more relevant for oral than for parenteral or vaginal use and may cause sedation or other dose-related effects.
What this interaction means in plain words
Itraconazole and Progesterone natural can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 inhibition by itraconazole reduces progesterone metabolism.
What to do
Monitor for progestogenic adverse effects and consider reducing the progesterone dose if they appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Frequently asked questions
Can I take Itraconazole with Progesterone natural?
MediHelp rates the interaction as moderate. Itraconazole and Progesterone natural can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Itraconazole may increase exposure to natural progesterone because it is cleared mainly by CYP3A4. The effect is more relevant for oral than for parenteral or vaginal use and may cause sedation or other dose-related effects.
How serious is the interaction between Itraconazole and Progesterone natural?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for progestogenic adverse effects and consider reducing the progesterone dose if they appear.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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