Drug interactions
Itraconazole + Promazine
Severity: Major
Itraconazole and Promazine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can prolong the QTc interval, so the combination may raise the risk of torsades de pointes. Risk is greater with electrolyte disturbance, bradycardia or structural heart disease.
What this interaction means in plain words
Itraconazole and Promazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive QT prolongation; itraconazole may also inhibit promazine metabolism.
What to do
Avoid if possible. Otherwise obtain a baseline ECG, correct electrolytes and monitor QTc.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Frequently asked questions
Can I take Itraconazole with Promazine?
MediHelp rates the interaction as major. Itraconazole and Promazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents can prolong the QTc interval, so the combination may raise the risk of torsades de pointes. Risk is greater with electrolyte disturbance, bradycardia or structural heart disease.
How serious is the interaction between Itraconazole and Promazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible. Otherwise obtain a baseline ECG, correct electrolytes and monitor QTc.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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