Drug interactions
Itraconazole + Quinupristin / dalfopristin
Severity: Moderate
Itraconazole and Quinupristin / dalfopristin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinupristin/dalfopristin inhibits CYP3A4, and itraconazole is a CYP3A4 substrate, so itraconazole levels may increase. Itraconazole itself is a strong inhibitor, so the added effect is likely limited.
What this interaction means in plain words
Itraconazole and Quinupristin / dalfopristin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 inhibition by quinupristin/dalfopristin reduces itraconazole metabolism.
What to do
Monitor for itraconazole adverse effects, including heart failure and liver toxicity. Obtain an ECG if other QT-prolonging drugs are used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Frequently asked questions
Can I take Itraconazole with Quinupristin / dalfopristin?
MediHelp rates the interaction as moderate. Itraconazole and Quinupristin / dalfopristin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinupristin/dalfopristin inhibits CYP3A4, and itraconazole is a CYP3A4 substrate, so itraconazole levels may increase. Itraconazole itself is a strong inhibitor, so the added effect is likely limited.
How serious is the interaction between Itraconazole and Quinupristin / dalfopristin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for itraconazole adverse effects, including heart failure and liver toxicity. Obtain an ECG if other QT-prolonging drugs are used.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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