Drug interactions
Itraconazole + Saccharomyces boulardii
Severity: Moderate
Itraconazole and Saccharomyces boulardii: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Saccharomyces boulardii is a live yeast, and systemic antifungals may reduce its viability and probiotic effect. Oral itraconazole may have this effect in the gut, and fungemia risk with the probiotic is a separate concern in vulnerable patients.
What this interaction means in plain words
Itraconazole and Saccharomyces boulardii can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Antifungal activity against the yeast probiotic reduces its viability.
What to do
Avoid using the probiotic during itraconazole therapy, as benefit is likely to be lost. Use an alternative probiotic if one is required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Frequently asked questions
Can I take Itraconazole with Saccharomyces boulardii?
MediHelp rates the interaction as moderate. Itraconazole and Saccharomyces boulardii can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Saccharomyces boulardii is a live yeast, and systemic antifungals may reduce its viability and probiotic effect. Oral itraconazole may have this effect in the gut, and fungemia risk with the probiotic is a separate concern in vulnerable patients.
How serious is the interaction between Itraconazole and Saccharomyces boulardii?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using the probiotic during itraconazole therapy, as benefit is likely to be lost. Use an alternative probiotic if one is required.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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