Drug interactions
Itraconazole + Triazolam
Severity: Contraindicated
Itraconazole and Triazolam: contraindicated interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole greatly increases and prolongs triazolam exposure, leading to profound sedation, amnesia and respiratory depression. The effect can persist for days because triazolam clearance is severely reduced.
What this interaction means in plain words
Itraconazole and Triazolam are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Potent inhibition of CYP3A4 by itraconazole blocks the primary metabolic clearance of triazolam.
What to do
Do not co-administer; use an alternative hypnotic less dependent on CYP3A4 (e.g., temazepam) if an antifungal azole is required.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Frequently asked questions
Can I take Itraconazole with Triazolam?
MediHelp rates the interaction as contraindicated. Itraconazole and Triazolam are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Itraconazole greatly increases and prolongs triazolam exposure, leading to profound sedation, amnesia and respiratory depression. The effect can persist for days because triazolam clearance is severely reduced.
How serious is the interaction between Itraconazole and Triazolam?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; use an alternative hypnotic less dependent on CYP3A4 (e.g., temazepam) if an antifungal azole is required.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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