Drug interactions
Itraconazole + Trifluoperazine
Severity: Major
Itraconazole and Trifluoperazine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs may prolong the QT interval, so combined use may increase the risk of ventricular arrhythmias including torsades de pointes. The risk is higher with hypokalemia, hypomagnesemia or cardiac disease.
What this interaction means in plain words
Itraconazole and Trifluoperazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive QTc prolongation.
What to do
Avoid if an alternative exists. If combined, obtain a baseline and follow-up ECG and keep potassium and magnesium within normal range.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Frequently asked questions
Can I take Itraconazole with Trifluoperazine?
MediHelp rates the interaction as major. Itraconazole and Trifluoperazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs may prolong the QT interval, so combined use may increase the risk of ventricular arrhythmias including torsades de pointes. The risk is higher with hypokalemia, hypomagnesemia or cardiac disease.
How serious is the interaction between Itraconazole and Trifluoperazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if an alternative exists. If combined, obtain a baseline and follow-up ECG and keep potassium and magnesium within normal range.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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