Drug interactions
Itraconazole + Tropisetron
Severity: Moderate
Itraconazole and Tropisetron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole can prolong the QT interval and tropisetron may have small effects on cardiac conduction. Together they could add to proarrhythmic risk. Itraconazole may also modestly raise tropisetron exposure through CYP3A4 inhibition.
What this interaction means in plain words
Itraconazole and Tropisetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation, with possible CYP3A4 inhibition by itraconazole reducing tropisetron clearance.
What to do
Check electrolytes and obtain an ECG in patients with cardiac risk factors or other QT-prolonging drugs. Consider a different antiemetic if the QTc is prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Frequently asked questions
Can I take Itraconazole with Tropisetron?
MediHelp rates the interaction as moderate. Itraconazole and Tropisetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Itraconazole can prolong the QT interval and tropisetron may have small effects on cardiac conduction. Together they could add to proarrhythmic risk. Itraconazole may also modestly raise tropisetron exposure through CYP3A4 inhibition.
How serious is the interaction between Itraconazole and Tropisetron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check electrolytes and obtain an ECG in patients with cardiac risk factors or other QT-prolonging drugs. Consider a different antiemetic if the QTc is prolonged.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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