Drug interactions
Itraconazole + Ulipristal
Severity: Moderate
Itraconazole and Ulipristal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole can raise ulipristal exposure, which could increase adverse effects. For single-dose emergency contraception the clinical significance is probably limited, but repeated-dose use for fibroids carries more concern.
What this interaction means in plain words
Itraconazole and Ulipristal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Strong CYP3A4 inhibition reduces ulipristal metabolism.
What to do
Avoid combination with repeated-dose ulipristal for fibroids. For emergency contraception, no dose change is needed, but counsel on possible increased side effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Frequently asked questions
Can I take Itraconazole with Ulipristal?
MediHelp rates the interaction as moderate. Itraconazole and Ulipristal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Itraconazole can raise ulipristal exposure, which could increase adverse effects. For single-dose emergency contraception the clinical significance is probably limited, but repeated-dose use for fibroids carries more concern.
How serious is the interaction between Itraconazole and Ulipristal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combination with repeated-dose ulipristal for fibroids. For emergency contraception, no dose change is needed, but counsel on possible increased side effects.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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