Drug interactions
Itraconazole + Venlafaxine
Severity: Moderate
Itraconazole and Venlafaxine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Venlafaxine can prolong the QTc interval at higher doses, and itraconazole may raise venlafaxine levels and has its own QT effect. The combination may increase the risk of arrhythmia and serotonergic or hypertensive adverse effects.
What this interaction means in plain words
Itraconazole and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Itraconazole belongs to Anti Fungals; Venlafaxine belongs to Central Nervous System.
Why it happens
Additive QT prolongation and CYP3A4 inhibition reducing minor venlafaxine metabolism, with CYP2D6 being the main route.
What to do
Monitor ECG in patients with cardiac risk factors, check blood pressure, and use the lowest effective venlafaxine dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicated
- Methylene blue + Venlafaxine Contraindicated
- Phenelzine + Venlafaxine Contraindicated
- Procarbazine + Venlafaxine Contraindicated
- Rasagiline + Venlafaxine Contraindicated
- Safinamide + Venlafaxine Contraindicated
Frequently asked questions
Can I take Itraconazole with Venlafaxine?
MediHelp rates the interaction as moderate. Itraconazole and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Venlafaxine can prolong the QTc interval at higher doses, and itraconazole may raise venlafaxine levels and has its own QT effect. The combination may increase the risk of arrhythmia and serotonergic or hypertensive adverse effects.
How serious is the interaction between Itraconazole and Venlafaxine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG in patients with cardiac risk factors, check blood pressure, and use the lowest effective venlafaxine dose.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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