Drug interactions
Itraconazole + Vilanterol / fluticasone furoate inhaled
Severity: Moderate
Itraconazole and Vilanterol / fluticasone furoate inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole can increase systemic exposure to both vilanterol and fluticasone furoate. This may cause beta-agonist cardiovascular effects, QT prolongation, and corticosteroid effects such as adrenal suppression.
What this interaction means in plain words
Itraconazole and Vilanterol / fluticasone furoate inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Strong CYP3A4 inhibition reduces the metabolism of both vilanterol and fluticasone furoate.
What to do
Monitor for tachycardia, hypokalemia and signs of systemic corticosteroid excess, especially with prolonged use. Consider an alternative antifungal or inhaler if these occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Frequently asked questions
Can I take Itraconazole with Vilanterol / fluticasone furoate inhaled?
MediHelp rates the interaction as moderate. Itraconazole and Vilanterol / fluticasone furoate inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Itraconazole can increase systemic exposure to both vilanterol and fluticasone furoate. This may cause beta-agonist cardiovascular effects, QT prolongation, and corticosteroid effects such as adrenal suppression.
How serious is the interaction between Itraconazole and Vilanterol / fluticasone furoate inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tachycardia, hypokalemia and signs of systemic corticosteroid excess, especially with prolonged use. Consider an alternative antifungal or inhaler if these occur.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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