Drug interactions
Itraconazole + Vincristine liposomal
Severity: Major
Itraconazole and Vincristine liposomal: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole can raise vincristine exposure, increasing the risk of neurotoxicity such as peripheral neuropathy, constipation, paralytic ileus and seizures. Case reports describe severe neurotoxicity when vinca alkaloids are given with azole antifungals.
What this interaction means in plain words
Itraconazole and Vincristine liposomal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Itraconazole inhibits CYP3A4 and P-glycoprotein, reducing vincristine metabolism and efflux.
What to do
Prefer a non-azole antifungal such as an echinocandin during vincristine therapy where possible. If the combination is unavoidable, monitor closely for neuropathy and bowel dysfunction and reduce or hold vincristine if toxicity develops.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Itraconazole and Vincristine liposomal, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
References
Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Frequently asked questions
Can I take Itraconazole with Vincristine liposomal?
MediHelp rates the interaction as major. Itraconazole and Vincristine liposomal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Itraconazole can raise vincristine exposure, increasing the risk of neurotoxicity such as peripheral neuropathy, constipation, paralytic ileus and seizures. Case reports describe severe neurotoxicity when vinca alkaloids are given with azole antifungals.
How serious is the interaction between Itraconazole and Vincristine liposomal?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-azole antifungal such as an echinocandin during vincristine therapy where possible. If the combination is unavoidable, monitor closely for neuropathy and bowel dysfunction and reduce or hold vincristine if toxicity develops.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
