Drug interactions
Itraconazole + Zaleplon
Severity: Minor
Itraconazole and Zaleplon: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole may modestly raise zaleplon levels, increasing sedation and psychomotor impairment. Zaleplon is mainly metabolized by aldehyde oxidase, with CYP3A4 as a secondary route.
What this interaction means in plain words
Itraconazole and Zaleplon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Itraconazole belongs to Anti Fungals; Zaleplon belongs to Central Nervous System.
Why it happens
Inhibition of the secondary CYP3A4 pathway of zaleplon metabolism.
What to do
No dose change is usually needed; warn the patient about next-day drowsiness and use the lowest zaleplon dose.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Zaleplon
- Calcium / magnesium / potassium / sodium oxybates + Zaleplon Contraindicated
- Sodium oxybate + Zaleplon Contraindicated
- Brexanolone + Zaleplon Major
- Buprenorphine long-acting + Zaleplon Major
- Buprenorphine subdermal implant + Zaleplon Major
- Buprenorphine transdermal + Zaleplon Major
Frequently asked questions
Can I take Itraconazole with Zaleplon?
MediHelp rates the interaction as minor. Itraconazole and Zaleplon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Itraconazole may modestly raise zaleplon levels, increasing sedation and psychomotor impairment. Zaleplon is mainly metabolized by aldehyde oxidase, with CYP3A4 as a secondary route.
How serious is the interaction between Itraconazole and Zaleplon?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; warn the patient about next-day drowsiness and use the lowest zaleplon dose.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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