Drug interactions
Itraconazole + Zolpidem
Severity: Minor
Itraconazole and Zolpidem: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole can modestly increase zolpidem exposure, with slightly greater sedation and impaired alertness. Studies show a small change that is rarely clinically important.
What this interaction means in plain words
Itraconazole and Zolpidem have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Itraconazole belongs to Anti Fungals; Zolpidem belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4-mediated zolpidem metabolism.
What to do
Usually no adjustment is needed; counsel about residual drowsiness and consider a lower zolpidem dose in older or frail patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Zolpidem
Frequently asked questions
Can I take Itraconazole with Zolpidem?
MediHelp rates the interaction as minor. Itraconazole and Zolpidem have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Itraconazole can modestly increase zolpidem exposure, with slightly greater sedation and impaired alertness. Studies show a small change that is rarely clinically important.
How serious is the interaction between Itraconazole and Zolpidem?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Usually no adjustment is needed; counsel about residual drowsiness and consider a lower zolpidem dose in older or frail patients.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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