Drug interactions
Ivabradine + Nafcillin
Severity: Moderate
Ivabradine and Nafcillin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nafcillin is a CYP3A4 inducer and may lower ivabradine concentrations. Diminished effect on heart rate could reduce symptom control.
What this interaction means in plain words
Ivabradine and Nafcillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Nafcillin induces CYP3A4, increasing the metabolic clearance of ivabradine.
What to do
Monitor heart rate and symptom control during nafcillin therapy and for a period after it ends. Consider an alternative antibiotic if ivabradine efficacy is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ivabradine
- Atazanavir + Ivabradine Contraindicated
- Clarithromycin + Ivabradine Contraindicated
- Cobicistat + Ivabradine Contraindicated
- Conivaptan + Ivabradine Contraindicated
- Darunavir + Ivabradine Contraindicated
- Diltiazem + Ivabradine Contraindicated
Frequently asked questions
Can I take Ivabradine with Nafcillin?
MediHelp rates the interaction as moderate. Ivabradine and Nafcillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nafcillin is a CYP3A4 inducer and may lower ivabradine concentrations. Diminished effect on heart rate could reduce symptom control.
How serious is the interaction between Ivabradine and Nafcillin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and symptom control during nafcillin therapy and for a period after it ends. Consider an alternative antibiotic if ivabradine efficacy is lost.
What other medicines interact with Ivabradine?
MediHelp also lists interactions of Ivabradine with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Ivabradine page.
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