Drug interactions
Ivabradine + Nefazodone
Severity: Contraindicated
Ivabradine and Nefazodone: contraindicated interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nefazodone is a strong CYP3A4 inhibitor and raises ivabradine plasma concentrations. This increases the likelihood of significant bradycardia and conduction block.
What this interaction means in plain words
Ivabradine and Nefazodone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Nefazodone inhibits CYP3A4, decreasing ivabradine clearance.
What to do
Do not co-administer; use a different antidepressant that does not inhibit CYP3A4.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Ivabradine
- Atazanavir + Ivabradine Contraindicated
- Clarithromycin + Ivabradine Contraindicated
- Cobicistat + Ivabradine Contraindicated
- Conivaptan + Ivabradine Contraindicated
- Darunavir + Ivabradine Contraindicated
- Diltiazem + Ivabradine Contraindicated
Frequently asked questions
Can I take Ivabradine with Nefazodone?
MediHelp rates the interaction as contraindicated. Ivabradine and Nefazodone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Nefazodone is a strong CYP3A4 inhibitor and raises ivabradine plasma concentrations. This increases the likelihood of significant bradycardia and conduction block.
How serious is the interaction between Ivabradine and Nefazodone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; use a different antidepressant that does not inhibit CYP3A4.
What other medicines interact with Ivabradine?
MediHelp also lists interactions of Ivabradine with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Ivabradine page.
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