Drug interactions
Ivabradine + Penbutolol
Severity: Moderate
Ivabradine and Penbutolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents lower heart rate, so combined use increases the risk of bradycardia and conduction disturbance. Dizziness, fatigue and hypotension may result.
What this interaction means in plain words
Ivabradine and Penbutolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive negative chronotropic effect from If-current inhibition and beta-adrenergic blockade.
What to do
Monitor heart rate and symptoms during initiation and titration of either drug. Reduce or discontinue ivabradine if resting heart rate stays below about 50 beats per minute or bradycardic symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ivabradine
- Atazanavir + Ivabradine Contraindicated
- Clarithromycin + Ivabradine Contraindicated
- Cobicistat + Ivabradine Contraindicated
- Conivaptan + Ivabradine Contraindicated
- Darunavir + Ivabradine Contraindicated
- Diltiazem + Ivabradine Contraindicated
Frequently asked questions
Can I take Ivabradine with Penbutolol?
MediHelp rates the interaction as moderate. Ivabradine and Penbutolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents lower heart rate, so combined use increases the risk of bradycardia and conduction disturbance. Dizziness, fatigue and hypotension may result.
How serious is the interaction between Ivabradine and Penbutolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and symptoms during initiation and titration of either drug. Reduce or discontinue ivabradine if resting heart rate stays below about 50 beats per minute or bradycardic symptoms occur.
What other medicines interact with Ivabradine?
MediHelp also lists interactions of Ivabradine with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Ivabradine page.
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