Drug interactions
Ivabradine + Pentobarbital
Severity: Moderate
Ivabradine and Pentobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates induce CYP3A4 and may reduce ivabradine concentrations. This could lessen heart rate lowering and therapeutic benefit.
What this interaction means in plain words
Ivabradine and Pentobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pentobarbital induces hepatic and intestinal CYP3A4, accelerating ivabradine metabolism.
What to do
Monitor heart rate and clinical response, and titrate ivabradine as needed. Use an alternative sedative if the effect is lost and the combination can be avoided.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ivabradine
- Atazanavir + Ivabradine Contraindicated
- Clarithromycin + Ivabradine Contraindicated
- Cobicistat + Ivabradine Contraindicated
- Conivaptan + Ivabradine Contraindicated
- Darunavir + Ivabradine Contraindicated
- Diltiazem + Ivabradine Contraindicated
Frequently asked questions
Can I take Ivabradine with Pentobarbital?
MediHelp rates the interaction as moderate. Ivabradine and Pentobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates induce CYP3A4 and may reduce ivabradine concentrations. This could lessen heart rate lowering and therapeutic benefit.
How serious is the interaction between Ivabradine and Pentobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and clinical response, and titrate ivabradine as needed. Use an alternative sedative if the effect is lost and the combination can be avoided.
What other medicines interact with Ivabradine?
MediHelp also lists interactions of Ivabradine with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Ivabradine page.
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