Drug interactions
Ivabradine + Pindolol
Severity: Moderate
Ivabradine and Pindolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs slow the heart, so combined use raises the risk of symptomatic bradycardia and conduction block. Pindolol has partial intrinsic sympathomimetic activity, which may lessen but not remove this effect.
What this interaction means in plain words
Ivabradine and Pindolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive negative chronotropic effect from If-current inhibition and beta-adrenergic blockade.
What to do
Monitor heart rate and symptoms during initiation and dose changes. Reduce or stop ivabradine if resting heart rate stays below about 50 beats per minute or symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ivabradine and Pindolol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Ivabradine
- Atazanavir + Ivabradine Contraindicated
- Clarithromycin + Ivabradine Contraindicated
- Cobicistat + Ivabradine Contraindicated
- Conivaptan + Ivabradine Contraindicated
- Darunavir + Ivabradine Contraindicated
- Diltiazem + Ivabradine Contraindicated
Frequently asked questions
Can I take Ivabradine with Pindolol?
MediHelp rates the interaction as moderate. Ivabradine and Pindolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs slow the heart, so combined use raises the risk of symptomatic bradycardia and conduction block. Pindolol has partial intrinsic sympathomimetic activity, which may lessen but not remove this effect.
How serious is the interaction between Ivabradine and Pindolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and symptoms during initiation and dose changes. Reduce or stop ivabradine if resting heart rate stays below about 50 beats per minute or symptoms occur.
What other medicines interact with Ivabradine?
MediHelp also lists interactions of Ivabradine with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Ivabradine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
