Drug interactions
Ivabradine + Schisandra
Severity: Moderate
Ivabradine and Schisandra: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Schisandra constituents inhibit CYP3A4 in vitro and in some human studies, which could raise ivabradine concentrations. This may increase the risk of bradycardia and visual disturbances.
What this interaction means in plain words
Ivabradine and Schisandra can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Schisandra lignans inhibit CYP3A4, potentially reducing ivabradine metabolism.
What to do
Advise patients to avoid schisandra supplements while on ivabradine. If used, monitor heart rate and ECG for bradycardia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ivabradine
- Atazanavir + Ivabradine Contraindicated
- Clarithromycin + Ivabradine Contraindicated
- Cobicistat + Ivabradine Contraindicated
- Conivaptan + Ivabradine Contraindicated
- Darunavir + Ivabradine Contraindicated
- Diltiazem + Ivabradine Contraindicated
Frequently asked questions
Can I take Ivabradine with Schisandra?
MediHelp rates the interaction as moderate. Ivabradine and Schisandra can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Schisandra constituents inhibit CYP3A4 in vitro and in some human studies, which could raise ivabradine concentrations. This may increase the risk of bradycardia and visual disturbances.
How serious is the interaction between Ivabradine and Schisandra?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid schisandra supplements while on ivabradine. If used, monitor heart rate and ECG for bradycardia.
What other medicines interact with Ivabradine?
MediHelp also lists interactions of Ivabradine with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Ivabradine page.
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