Drug interactions
Ivacaftor + Metformin-sitagliptin
Severity: Minor
Ivacaftor and Metformin-sitagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivacaftor and its metabolite can weakly inhibit P-glycoprotein and may increase sitagliptin concentrations. Sitagliptin has a wide therapeutic index, so clinically important effects are unlikely.
What this interaction means in plain words
Ivacaftor and Metformin-sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ivacaftor belongs to Miscellaneous; Metformin-sitagliptin belongs to Endocrine.
Why it happens
Weak P-glycoprotein inhibition reduces sitagliptin efflux and increases its exposure.
What to do
No dose adjustment is usually required; monitor for sitagliptin adverse effects and glycemic response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-sitagliptin
Other interactions of Ivacaftor
- Ensitrelvir + Ivacaftor Contraindicated
- Apalutamide + Ivacaftor Major
- Carbamazepine + Ivacaftor Major
- Clarithromycin + Ivacaftor Major
- Efavirenz + Ivacaftor Major
- Enzalutamide + Ivacaftor Major
Frequently asked questions
Can I take Ivacaftor with Metformin-sitagliptin?
MediHelp rates the interaction as minor. Ivacaftor and Metformin-sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ivacaftor and its metabolite can weakly inhibit P-glycoprotein and may increase sitagliptin concentrations. Sitagliptin has a wide therapeutic index, so clinically important effects are unlikely.
How serious is the interaction between Ivacaftor and Metformin-sitagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually required; monitor for sitagliptin adverse effects and glycemic response.
What other medicines interact with Metformin-sitagliptin?
MediHelp also lists interactions of Metformin-sitagliptin with, for example, Clozapine, Contrast media, Diatrizoate meglumine / diatrizoate. The full list is on the Metformin-sitagliptin page.
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