Drug interactions
Ivosidenib + Lesinurad
Severity: Moderate
Ivosidenib and Lesinurad: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib induces CYP3A4 and may affect other enzymes, but lesinurad is a CYP2C9 substrate and the net effect is not well characterized. Reduced lesinurad exposure and urate-lowering effect is possible.
What this interaction means in plain words
Ivosidenib and Lesinurad can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ivosidenib belongs to Oncology; Lesinurad belongs to Genitourinary.
Why it happens
Ivosidenib enzyme induction may increase CYP2C9-mediated clearance of lesinurad, though the effect is not well established.
What to do
Monitor serum urate for reduced efficacy and consider alternative urate-lowering therapy if response is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lesinurad
- Lesinurad + Norethisterone Major
- Acetylsalicylic acid + Lesinurad Moderate
- Amiodarone + Lesinurad Moderate
- Apalutamide + Lesinurad Moderate
- Desogestrel-ethinyl estradiol + Lesinurad Moderate
- Dienogest / estradiol valerate + Lesinurad Moderate
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Ivosidenib with Lesinurad?
MediHelp rates the interaction as moderate. Ivosidenib and Lesinurad can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ivosidenib induces CYP3A4 and may affect other enzymes, but lesinurad is a CYP2C9 substrate and the net effect is not well characterized. Reduced lesinurad exposure and urate-lowering effect is possible.
How serious is the interaction between Ivosidenib and Lesinurad?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum urate for reduced efficacy and consider alternative urate-lowering therapy if response is lost.
What other medicines interact with Lesinurad?
MediHelp also lists interactions of Lesinurad with, for example, Norethisterone, Acetylsalicylic acid, Amiodarone. The full list is on the Lesinurad page.
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