Drug interactions
Ivosidenib + Metaxalone
Severity: Moderate
Ivosidenib and Metaxalone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib induces CYP3A4, which may lower metaxalone concentrations. Muscle relaxant effect could be reduced.
What this interaction means in plain words
Ivosidenib and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ivosidenib belongs to Oncology; Metaxalone belongs to Musculoskeletal.
Why it happens
Ivosidenib induces CYP3A4, increasing the metabolism of metaxalone.
What to do
Monitor for reduced muscle relaxant efficacy and consider a dose adjustment or alternative agent if response is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metaxalone
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Ivosidenib with Metaxalone?
MediHelp rates the interaction as moderate. Ivosidenib and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ivosidenib induces CYP3A4, which may lower metaxalone concentrations. Muscle relaxant effect could be reduced.
How serious is the interaction between Ivosidenib and Metaxalone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced muscle relaxant efficacy and consider a dose adjustment or alternative agent if response is lost.
What other medicines interact with Metaxalone?
MediHelp also lists interactions of Metaxalone with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Metaxalone page.
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