Drug interactions
Ivosidenib + Nicardipine
Severity: Moderate
Ivosidenib and Nicardipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib induces CYP3A4 and can lower nicardipine concentrations, reducing blood pressure control. The loss of effect may be gradual after ivosidenib is started.
What this interaction means in plain words
Ivosidenib and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ivosidenib belongs to Oncology; Nicardipine belongs to Cardiovascular.
Why it happens
Ivosidenib induces CYP3A4, increasing nicardipine metabolism.
What to do
Monitor blood pressure and titrate nicardipine upward as needed, or switch to an antihypertensive not dependent on CYP3A4. Reassess the dose when ivosidenib is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nicardipine
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Ivosidenib with Nicardipine?
MediHelp rates the interaction as moderate. Ivosidenib and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ivosidenib induces CYP3A4 and can lower nicardipine concentrations, reducing blood pressure control. The loss of effect may be gradual after ivosidenib is started.
How serious is the interaction between Ivosidenib and Nicardipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and titrate nicardipine upward as needed, or switch to an antihypertensive not dependent on CYP3A4. Reassess the dose when ivosidenib is stopped.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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