Drug interactions
Ivosidenib + Nimodipine
Severity: Moderate
Ivosidenib and Nimodipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib induces CYP3A4 and may lower nimodipine concentrations. Reduced exposure may lessen the intended benefit, for example in subarachnoid hemorrhage.
What this interaction means in plain words
Ivosidenib and Nimodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ivosidenib belongs to Oncology; Nimodipine belongs to Cardiovascular.
Why it happens
Ivosidenib induces CYP3A4, increasing nimodipine metabolism.
What to do
Monitor clinical response and blood pressure, and consider an alternative or dose adjustment if efficacy appears reduced.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nimodipine
- Apalutamide + Nimodipine Major
- Carbamazepine + Nimodipine Major
- Ceritinib + Nimodipine Major
- Clarithromycin + Nimodipine Major
- Cobicistat + Nimodipine Major
- Darunavir + Nimodipine Major
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Ivosidenib with Nimodipine?
MediHelp rates the interaction as moderate. Ivosidenib and Nimodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ivosidenib induces CYP3A4 and may lower nimodipine concentrations. Reduced exposure may lessen the intended benefit, for example in subarachnoid hemorrhage.
How serious is the interaction between Ivosidenib and Nimodipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and blood pressure, and consider an alternative or dose adjustment if efficacy appears reduced.
What other medicines interact with Nimodipine?
MediHelp also lists interactions of Nimodipine with, for example, Apalutamide, Carbamazepine, Ceritinib. The full list is on the Nimodipine page.
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