Drug interactions
Ivosidenib + Primaquine
Severity: Major
Ivosidenib and Primaquine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib induces CYP3A4 and may reduce primaquine exposure, potentially compromising antimalarial efficacy. Ivosidenib also prolongs the QT interval, and primaquine may add to this effect.
What this interaction means in plain words
Ivosidenib and Primaquine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ivosidenib belongs to Oncology; Primaquine belongs to Anti Parasitic.
Why it happens
CYP3A4 induction by ivosidenib, plus additive QT prolongation.
What to do
Avoid the combination if possible. If it is necessary, monitor the ECG and electrolytes and watch for primaquine treatment failure.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Primaquine
- Pimozide + Primaquine Contraindicated
- Amiodarone + Primaquine Major
- Amisulpride + Primaquine Major
- Anagrelide + Primaquine Major
- Arsenic trioxide + Primaquine Major
- Asenapine + Primaquine Major
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Ivosidenib with Primaquine?
MediHelp rates the interaction as major. Ivosidenib and Primaquine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ivosidenib induces CYP3A4 and may reduce primaquine exposure, potentially compromising antimalarial efficacy. Ivosidenib also prolongs the QT interval, and primaquine may add to this effect.
How serious is the interaction between Ivosidenib and Primaquine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If it is necessary, monitor the ECG and electrolytes and watch for primaquine treatment failure.
What other medicines interact with Primaquine?
MediHelp also lists interactions of Primaquine with, for example, Pimozide, Amiodarone, Amisulpride. The full list is on the Primaquine page.
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