Drug interactions
Ivosidenib + Roflumilast
Severity: Moderate
Ivosidenib and Roflumilast: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib induces CYP3A4 and may lower roflumilast exposure. This could reduce efficacy in preventing COPD exacerbations.
What this interaction means in plain words
Ivosidenib and Roflumilast can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ivosidenib belongs to Oncology; Roflumilast belongs to Respiratory.
Why it happens
Ivosidenib induces CYP3A4, increasing roflumilast metabolism.
What to do
Monitor for loss of roflumilast effect and consider alternative therapy if COPD control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Roflumilast
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Ivosidenib with Roflumilast?
MediHelp rates the interaction as moderate. Ivosidenib and Roflumilast can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ivosidenib induces CYP3A4 and may lower roflumilast exposure. This could reduce efficacy in preventing COPD exacerbations.
How serious is the interaction between Ivosidenib and Roflumilast?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of roflumilast effect and consider alternative therapy if COPD control worsens.
What other medicines interact with Roflumilast?
MediHelp also lists interactions of Roflumilast with, for example, Apalutamide, Carbamazepine, Efavirenz. The full list is on the Roflumilast page.
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