Drug interactions
Ivosidenib + Saxagliptin-metformin
Severity: Minor
Ivosidenib and Saxagliptin-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib induces CYP3A4 and may lower saxagliptin active exposure, potentially reducing glycemic efficacy. The magnitude is uncertain.
What this interaction means in plain words
Ivosidenib and Saxagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ivosidenib belongs to Oncology; Saxagliptin-metformin belongs to Endocrine.
Why it happens
Ivosidenib induces CYP3A4, altering saxagliptin metabolism.
What to do
Monitor blood glucose and HbA1c and adjust antidiabetic therapy if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Saxagliptin-metformin
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Ivosidenib with Saxagliptin-metformin?
MediHelp rates the interaction as minor. Ivosidenib and Saxagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ivosidenib induces CYP3A4 and may lower saxagliptin active exposure, potentially reducing glycemic efficacy. The magnitude is uncertain.
How serious is the interaction between Ivosidenib and Saxagliptin-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c and adjust antidiabetic therapy if control worsens.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
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