Drug interactions
Ivosidenib + Sertraline
Severity: Moderate
Ivosidenib and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib prolongs the QT interval, and sertraline adds a modest effect. Ivosidenib also induces CYP3A4 and may modestly lower sertraline levels. The combination raises the risk of QT-related arrhythmia.
What this interaction means in plain words
Ivosidenib and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ivosidenib belongs to Oncology; Sertraline belongs to Central Nervous System.
Why it happens
Additive QT prolongation, with possible reduction in sertraline exposure through CYP3A4 induction.
What to do
Monitor the ECG and electrolytes at baseline and regularly during treatment. Reduce or hold ivosidenib if the QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Ivosidenib with Sertraline?
MediHelp rates the interaction as moderate. Ivosidenib and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ivosidenib prolongs the QT interval, and sertraline adds a modest effect. Ivosidenib also induces CYP3A4 and may modestly lower sertraline levels. The combination raises the risk of QT-related arrhythmia.
How serious is the interaction between Ivosidenib and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor the ECG and electrolytes at baseline and regularly during treatment. Reduce or hold ivosidenib if the QTc becomes markedly prolonged.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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