Drug interactions
Ivosidenib + Tolbutamide
Severity: Moderate
Ivosidenib and Tolbutamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib can induce CYP2C9, which may lower tolbutamide concentrations. This may reduce glucose-lowering effect and worsen glycemic control.
What this interaction means in plain words
Ivosidenib and Tolbutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ivosidenib belongs to Oncology; Tolbutamide belongs to Endocrine.
Why it happens
Ivosidenib induces CYP2C9, increasing metabolism of tolbutamide.
What to do
Monitor blood glucose closely when ivosidenib is started or stopped. Increase tolbutamide dose or choose an alternative antidiabetic agent if control is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolbutamide
- Glyburide-metformin + Tolbutamide Major
- Insulin degludec-liraglutide + Tolbutamide Major
- Aceclofenac + Tolbutamide Moderate
- Acemetacin + Tolbutamide Moderate
- Acetylsalicylic acid + Tolbutamide Moderate
- Albiglutide + Tolbutamide Moderate
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Ivosidenib with Tolbutamide?
MediHelp rates the interaction as moderate. Ivosidenib and Tolbutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ivosidenib can induce CYP2C9, which may lower tolbutamide concentrations. This may reduce glucose-lowering effect and worsen glycemic control.
How serious is the interaction between Ivosidenib and Tolbutamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when ivosidenib is started or stopped. Increase tolbutamide dose or choose an alternative antidiabetic agent if control is lost.
What other medicines interact with Tolbutamide?
MediHelp also lists interactions of Tolbutamide with, for example, Glyburide-metformin, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolbutamide page.
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