Drug interactions
Ivosidenib + Vardenafil
Severity: Moderate
Ivosidenib and Vardenafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib can prolong the QT interval, and vardenafil adds a small effect. Ivosidenib also induces CYP3A4, which may lower vardenafil levels and reduce its efficacy.
What this interaction means in plain words
Ivosidenib and Vardenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ivosidenib belongs to Oncology; Vardenafil belongs to Genitourinary.
Why it happens
Additive QT prolongation, plus CYP3A4 induction by ivosidenib reducing vardenafil exposure.
What to do
Monitor ECG and electrolytes if the combination is needed. Watch for loss of erectile response and consider a different ED strategy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vardenafil
- Amyl nitrite + Vardenafil Contraindicated
- Glyceryl trinitrate pr + Vardenafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Isosorbide mononitrate + Vardenafil Contraindicated
- Nicorandil + Vardenafil Contraindicated
- Nitroglycerin po + Vardenafil Contraindicated
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Ivosidenib with Vardenafil?
MediHelp rates the interaction as moderate. Ivosidenib and Vardenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ivosidenib can prolong the QT interval, and vardenafil adds a small effect. Ivosidenib also induces CYP3A4, which may lower vardenafil levels and reduce its efficacy.
How serious is the interaction between Ivosidenib and Vardenafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes if the combination is needed. Watch for loss of erectile response and consider a different ED strategy.
What other medicines interact with Vardenafil?
MediHelp also lists interactions of Vardenafil with, for example, Amyl nitrite, Glyceryl trinitrate pr, Isosorbide dinitrate. The full list is on the Vardenafil page.
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