Drug interactions
Ivosidenib + Vinblastine
Severity: Moderate
Ivosidenib and Vinblastine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib induces CYP3A4 and may lower vinblastine exposure, potentially reducing its antitumor effect. The magnitude in patients is not well characterized.
What this interaction means in plain words
Ivosidenib and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ivosidenib belongs to Oncology; Vinblastine belongs to Oncology.
Why it happens
Ivosidenib induces CYP3A4, increasing vinblastine metabolism.
What to do
Monitor for reduced therapeutic response. Consider an alternative regimen if loss of efficacy is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vinblastine
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Ivosidenib with Vinblastine?
MediHelp rates the interaction as moderate. Ivosidenib and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ivosidenib induces CYP3A4 and may lower vinblastine exposure, potentially reducing its antitumor effect. The magnitude in patients is not well characterized.
How serious is the interaction between Ivosidenib and Vinblastine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced therapeutic response. Consider an alternative regimen if loss of efficacy is suspected.
What other medicines interact with Vinblastine?
MediHelp also lists interactions of Vinblastine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vinblastine page.
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