Drug interactions
Ivosidenib + Zafirlukast
Severity: Moderate
Ivosidenib and Zafirlukast: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib induces CYP enzymes and may lower concentrations of CYP2C9 substrates. Zafirlukast is mainly metabolised by CYP2C9, so its effect could be reduced and asthma control may worsen.
What this interaction means in plain words
Ivosidenib and Zafirlukast can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ivosidenib belongs to Oncology; Zafirlukast belongs to Respiratory.
Why it happens
Ivosidenib enzyme induction may increase CYP2C9 metabolism of zafirlukast, lowering exposure.
What to do
Monitor for loss of asthma control and consider an alternative controller if symptoms worsen.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zafirlukast
- Pimozide + Zafirlukast Contraindicated
- Lomitapide + Zafirlukast Major
- Nilotinib + Zafirlukast Major
- Warfarin + Zafirlukast Major
- Apalutamide + Zafirlukast Moderate
- Carbamazepine + Zafirlukast Moderate
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Ivosidenib with Zafirlukast?
MediHelp rates the interaction as moderate. Ivosidenib and Zafirlukast can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ivosidenib induces CYP enzymes and may lower concentrations of CYP2C9 substrates. Zafirlukast is mainly metabolised by CYP2C9, so its effect could be reduced and asthma control may worsen.
How serious is the interaction between Ivosidenib and Zafirlukast?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of asthma control and consider an alternative controller if symptoms worsen.
What other medicines interact with Zafirlukast?
MediHelp also lists interactions of Zafirlukast with, for example, Pimozide, Lomitapide, Nilotinib. The full list is on the Zafirlukast page.
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