Drug interactions
Japanese encephalitis virus vaccine + Mycophenolate mofetil
Severity: Moderate
Japanese encephalitis virus vaccine and Mycophenolate mofetil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Available Japanese encephalitis vaccines are inactivated, so mycophenolate mainly risks a weaker antibody response. Travellers on immunosuppression may be left with inadequate protection.
What this interaction means in plain words
Japanese encephalitis virus vaccine and Mycophenolate mofetil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Suppressed lymphocyte proliferation from IMPDH inhibition blunts vaccine-induced immunity.
What to do
Complete the series well before travel and consider checking neutralising antibody where available. Emphasise mosquito-bite avoidance regardless of vaccination.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mycophenolate mofetil
- Adenovirus types 4 and 7 live + Mycophenolate mofetil Contraindicated
- Bcg vaccine live + Mycophenolate mofetil Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Mycophenolate mofetil Contraindicated
- Measles mumps and rubella vaccine live + Mycophenolate mofetil Contraindicated
- Measles mumps rubella and varicella vaccine live + Mycophenolate mofetil Contraindicated
- Measles vaccine + Mycophenolate mofetil Contraindicated
Frequently asked questions
Can I take Japanese encephalitis virus vaccine with Mycophenolate mofetil?
MediHelp rates the interaction as moderate. Japanese encephalitis virus vaccine and Mycophenolate mofetil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Available Japanese encephalitis vaccines are inactivated, so mycophenolate mainly risks a weaker antibody response. Travellers on immunosuppression may be left with inadequate protection.
How serious is the interaction between Japanese encephalitis virus vaccine and Mycophenolate mofetil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Complete the series well before travel and consider checking neutralising antibody where available. Emphasise mosquito-bite avoidance regardless of vaccination.
What other medicines interact with Mycophenolate mofetil?
MediHelp also lists interactions of Mycophenolate mofetil with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Mycophenolate mofetil page.
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