Drug interactions
Japanese encephalitis virus vaccine + Oxaliplatin
Severity: Moderate
Japanese encephalitis virus vaccine and Oxaliplatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chemotherapy with oxaliplatin may impair the antibody response to inactivated Japanese encephalitis vaccine. Travelers on treatment may be left with inadequate protection.
What this interaction means in plain words
Japanese encephalitis virus vaccine and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cytotoxic myelosuppression and lymphopenia blunt the immune response to vaccine antigens.
What to do
Complete vaccination at least 2 weeks before chemotherapy when possible; otherwise consider checking serologic response or revaccinating after immune recovery, and reassess the need for travel.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Frequently asked questions
Can I take Japanese encephalitis virus vaccine with Oxaliplatin?
MediHelp rates the interaction as moderate. Japanese encephalitis virus vaccine and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chemotherapy with oxaliplatin may impair the antibody response to inactivated Japanese encephalitis vaccine. Travelers on treatment may be left with inadequate protection.
How serious is the interaction between Japanese encephalitis virus vaccine and Oxaliplatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Complete vaccination at least 2 weeks before chemotherapy when possible; otherwise consider checking serologic response or revaccinating after immune recovery, and reassess the need for travel.
What other medicines interact with Oxaliplatin?
MediHelp also lists interactions of Oxaliplatin with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Oxaliplatin page.
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