Drug interactions
Japanese encephalitis virus vaccine + Sirolimus
Severity: Moderate
Japanese encephalitis virus vaccine and Sirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sirolimus may reduce the response to Japanese encephalitis vaccine, which is inactivated in current products. Protection may be incomplete in travelers on immunosuppression.
What this interaction means in plain words
Japanese encephalitis virus vaccine and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Sirolimus immunosuppression impairs vaccine-induced antibody production.
What to do
Complete the vaccine series well before travel and consider checking neutralizing antibody; reinforce mosquito-avoidance measures.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Japanese encephalitis virus vaccine and Sirolimus, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Frequently asked questions
Can I take Japanese encephalitis virus vaccine with Sirolimus?
MediHelp rates the interaction as moderate. Japanese encephalitis virus vaccine and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sirolimus may reduce the response to Japanese encephalitis vaccine, which is inactivated in current products. Protection may be incomplete in travelers on immunosuppression.
How serious is the interaction between Japanese encephalitis virus vaccine and Sirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Complete the vaccine series well before travel and consider checking neutralizing antibody; reinforce mosquito-avoidance measures.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Sirolimus page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
