Drug interactions
Japanese encephalitis virus vaccine + Tacrolimus
Severity: Moderate
Japanese encephalitis virus vaccine and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tacrolimus may reduce the protective antibody response to Japanese encephalitis vaccine. Inactivated vaccines can be given to immunosuppressed patients, but protection may be incomplete. The live attenuated chimeric vaccine would carry additional infection risk.
What this interaction means in plain words
Japanese encephalitis virus vaccine and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Calcineurin inhibition impairs T-cell dependent antibody responses to vaccination.
What to do
Prefer the inactivated vaccine in patients on tacrolimus and complete the series well before travel. Check serologic response where it is available, and avoid the live vaccine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Japanese encephalitis virus vaccine with Tacrolimus?
MediHelp rates the interaction as moderate. Japanese encephalitis virus vaccine and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tacrolimus may reduce the protective antibody response to Japanese encephalitis vaccine. Inactivated vaccines can be given to immunosuppressed patients, but protection may be incomplete. The live attenuated chimeric vaccine would carry additional infection risk.
How serious is the interaction between Japanese encephalitis virus vaccine and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer the inactivated vaccine in patients on tacrolimus and complete the series well before travel. Check serologic response where it is available, and avoid the live vaccine.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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