Drug interactions
Ketamine + Nabilone
Severity: Moderate
Ketamine and Nabilone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs affect the CNS, so combined use may deepen sedation and impair cognition. Both can also cause psychotomimetic effects, anxiety and tachycardia, which may be more pronounced together.
What this interaction means in plain words
Ketamine and Nabilone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ketamine belongs to Central Nervous System; Nabilone belongs to Gastrointestinal Tract.
Why it happens
Additive CNS depression and psychoactive effects from NMDA antagonism and cannabinoid agonism, with additive sympathetic cardiovascular stimulation.
What to do
Monitor sedation level, psychiatric effects, heart rate and blood pressure, and consider a lower ketamine dose. Ensure appropriate monitoring and supervised recovery after procedural use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nabilone
Other interactions of Ketamine
Frequently asked questions
Can I take Ketamine with Nabilone?
MediHelp rates the interaction as moderate. Ketamine and Nabilone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs affect the CNS, so combined use may deepen sedation and impair cognition. Both can also cause psychotomimetic effects, anxiety and tachycardia, which may be more pronounced together.
How serious is the interaction between Ketamine and Nabilone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation level, psychiatric effects, heart rate and blood pressure, and consider a lower ketamine dose. Ensure appropriate monitoring and supervised recovery after procedural use.
What other medicines interact with Nabilone?
MediHelp also lists interactions of Nabilone with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Nabilone page.
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