Drug interactions
Ketamine + Perphenazine
Severity: Moderate
Ketamine and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can cause sedation and may add to hypotension and psychomotor impairment when used together. Ketamine's psychotomimetic effects may also complicate the clinical picture in patients treated with antipsychotics.
What this interaction means in plain words
Ketamine and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ketamine belongs to Central Nervous System; Perphenazine belongs to Central Nervous System.
Why it happens
Additive CNS depression and cardiovascular effects.
What to do
Monitor sedation, blood pressure and respiratory status during and after ketamine administration. Use the lowest effective ketamine dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Other interactions of Ketamine
Frequently asked questions
Can I take Ketamine with Perphenazine?
MediHelp rates the interaction as moderate. Ketamine and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can cause sedation and may add to hypotension and psychomotor impairment when used together. Ketamine's psychotomimetic effects may also complicate the clinical picture in patients treated with antipsychotics.
How serious is the interaction between Ketamine and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, blood pressure and respiratory status during and after ketamine administration. Use the lowest effective ketamine dose.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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